Disposition kinetics and metabolism of nicotine and cotinine in African American smokers
نویسندگان
چکیده
منابع مشابه
Metabolism and disposition kinetics of nicotine.
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a useful probe drug for phenotyping cytochrome P450 2A6 (CYP2A6). We review current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under develo...
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Background & objectives: The number of waterpipe cafes has considerably grown in Tehran and other cities of Iran. This increase has occurred due to a wrong belief that the use of hookahs is harmless and relatively safe. So, the aim of current study is to investigate the nicotine concentration in the indoor air of the waterpipe and cigarette cafés as well as the biological concentration of nicot...
متن کاملEvaluation of Antioxidant Capacity and Cotinine Levels of Saliva in Male Smokers and Non-smokers
Background: The cigarette compounds are associated with the increase in the incidence of oral cancer andprecancerous lesions. Salivary antioxidant system plays an important role in anti-carcinogenic capacity ofsaliva. Cotinine, a nicotine metabolite, has a longer half-life in comparison with nicotine and is a suitablemarker for exposure to cigarette smoke. This study aims to measure total antio...
متن کاملComparison of Cotinine Salivary Levels in Hookah Smokers, Passive Smokers, and Non-Smokers
Background: At present smoking is considered a great health-related problem. Smoking cigarettes and use of tobacco are on the rise in the Middle East countries; therefore, the number of people exposed to passive cigarette smoke is increasing, too. The aim of the present study was to determine and compare salivary cotinine levels in hookah smokers, individuals exposed to passive cigarette smoke ...
متن کاملNicotine and cotinine in the cervical mucus of smokers, passive smokers, and nonsmokers.
Although epidemiological studies suggest that cigarette smoking is a risk factor for cervical cancer, further evidence is required to document the biological plausibility of this relationship. This study obtained cervical mucus, using a cervical flush technique, from 50 patients in a neoplasia clinic. Nicotine was detected in the cervical mucus of all 25 smokers and cotinine in the mucus of 84%...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2016
ISSN: 1744-6872
DOI: 10.1097/fpc.0000000000000222